Lighting Up Genes in Single Cells at Scale.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26276626.
- Also identified by DOI 10.1016/j.cell.2015.07.052.
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Abstract
In this issue, Shachar et al. report a high-throughput imaging position mapping platform (HIPmap) enabling large-scale, high-resolution localization of 3D gene positions in single cells. Coupling loss-of-function screens with HIPmap, the authors identify DNA replication rather than mitosis as a major determinant of genome positioning.
Medical subject headings
- Cell Nucleus
- Genes
- Genetic Techniques