Somatic Rearrangement in B Cells: It's (Mostly) Nuclear Physics.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26276627.
- Also identified by DOI 10.1016/j.cell.2015.07.034 and PMC identifier 4537798.
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Abstract
We discuss how principles of nuclear architecture drive typical gene rearrangements in B lymphocytes, whereas translocation hot spots and recurrent lesions reflect the extent of AID-mediated DNA damage and selection.
Medical subject headings
- B-Lymphocytes
- Cell Nucleus
- Gene Rearrangement, B-Lymphocyte