The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?
Where this comes from
- Record sourced from PubMed, PMID 26289118.
- Also identified by DOI 10.1111/acel.12389 and PMC identifier 4693465.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Mitochondrial-derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA-c (MOTS-c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS-c encoding mtDNA, which is specific for the Northeast Asian population, may be among the putative biological mechanisms explaining the high longevity of Japanese people.
Medical subject headings
- Aging
- DNA, Mitochondrial
- Longevity
- Mitochondria
- Peptides
- RNA, Ribosomal