REDD1 Is Essential for Optimal T Cell Proliferation and Survival.
Where this comes from
- Record sourced from PubMed, PMID 26301899.
- Also identified by DOI 10.1371/journal.pone.0136323 and PMC identifier 4547781.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
REDD1 is a highly conserved stress response protein that is upregulated following many types of cellular stress, including hypoxia, DNA damage, energy stress, ER stress, and nutrient deprivation. Recently, REDD1 was shown to be involved in dexamethasone induced autophagy in murine thymocytes. However, we know little of REDD1's function in mature T cells. Here we show for the first time that REDD1 is upregulated following T cell stimulation with PHA or CD3/CD28 beads. REDD1 knockout T cells exhibit a defect in proliferation and cell survival, although markers of activation appear normal. These findings demonstrate a previously unappreciated role for REDD1 in T cell function.
Medical subject headings
- Autophagy
- Cell Proliferation
- Cell Survival
- Transcription Factors