Enzyme-Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26305446.
- Also identified by DOI 10.1002/adma.201502003 and PMC identifier 4699559.
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Abstract
A method for targeting to and retaining intravenously injected nanoparticles at the site of acute myocardial infarction in a rat model is described. Enzyme-responsive peptide-polymer amphiphiles are assembled as spherical micellar nanoparticles, and undergo a morphological transition from spherical-shaped, discrete materials to network-like assemblies when acted upon by matrix metalloproteinases (MMP-2 and MMP-9), which are up-regulated in heart tissue post-myocardial infarction.
Medical subject headings
- Drug Carriers
- Heart
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
- Myocardial Infarction
- Nanoparticles