Intracochlear Bleeding Enhances Cochlear Fibrosis and Ossification: An Animal Study.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26308864.
- Also identified by DOI 10.1371/journal.pone.0136617 and PMC identifier 4550248.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The aim of this study was to investigate the effects of intracochlear bleeding during cochleostomy on cochlear inflammatory response and residual hearing in a guinea pig animal model. Auditory brainstem response threshold shifts were greater in blood injected ears (p<0.05). Interleukin-1β, interleukin-10, tumor necrosis factor-α and nitric oxide synthase 2, cytokines that are related to early stage inflammation, were significantly increased in blood injected ears compared to normal and cochleostomy only ears at 1 day after surgery; with the increased IL-1β being sustained until 3 days after the surgery (p<0.05). Hair cells were more severely damaged in blood injected ears than in cochleostomy only ears. Histopathologic examination revealed more extensive fibrosis and ossification in blood injected ears than cochleostomy only ears. These results show that intracochlear bleeding enhanced cochlear inflammation resulting in increased fibrosis and ossification in an experimental animal model.
Medical subject headings
- Cochlea
- Cochlear Implantation
- Fibrosis
- Hearing Disorders
- Hemorrhage
- Ossification, Heterotopic
- Postoperative Complications