MiR-378b Promotes Differentiation of Keratinocytes through NKX3.1.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26313654.
- Also identified by DOI 10.1371/journal.pone.0136049 and PMC identifier 4551849.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
MicroRNA (miRNA) is a kind of short non-coding RNA, involved in various cellular processes. During keratinocyte differentiation, miRNAs act as important regulators. In this study, we demonstrated by microarray assay that the expression of miR-378b significantly increased during keratinocytes differentiation. Our findings showed that miR-378b could inhibit proliferation, migration and differentiation in keratinocytes. Luciferase reporter assays showed that miR-378b directly target NKX3.1. Silencing of NKX3.1 could coincide with the effects of miR-24 overexpression. In conclusion, our results demonstrate miR-378b promote keratinocytes differentiation by targeting NKX3.1. Manipulation of miR-378b may afford a new strategy to clinic treatment of skin injury and repair.
Medical subject headings
- Cell Differentiation
- Homeodomain Proteins
- Keratinocytes
- MicroRNAs
- Skin
- Transcription Factors