Removing roadblocks to deep sequencing of modified RNAs.
Level V
Where this comes from
- Record sourced from PubMed, PMID 26317237.
- Also identified by DOI 10.1038/nmeth.3516 and PMC identifier 4568847.
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Abstract
By removing modified nucleotides that block reverse transcriptase, two methods have now made tRNAs amenable to RNA-seq.
Medical subject headings
- Algorithms
- DNA Methylation
- Escherichia coli Proteins
- Gene Library
- High-Throughput Nucleotide Sequencing
- Mixed Function Oxygenases
- RNA, Transfer
- Software