A Long-Distance Chromatin Affair.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26317462.
- Also identified by DOI 10.1016/j.cell.2015.08.022.
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Abstract
Changes in transcription factor binding sequences result in correlated changes in chromatin composition locally and at sites hundreds of kilobases away. New studies demonstrate that this concordance is mediated via spatial chromatin interactions that constitute regulatory modules of the human genome.
Medical subject headings
- Chromatin
- Chromosomes, Human
- Gene Expression Regulation
- Genetic Variation
- Genome, Human
- Human Genome Project