Architectural and Functional Commonalities between Enhancers and Promoters.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 26317464.
- Also identified by DOI 10.1016/j.cell.2015.08.008 and PMC identifier 4556168.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
With the explosion of genome-wide studies of regulated transcription, it has become clear that traditional definitions of enhancers and promoters need to be revisited. These control elements can now be characterized in terms of their local and regional architecture, their regulatory components, including histone modifications and associated binding factors, and their functional contribution to transcription. This Review discusses unifying themes between promoters and enhancers in transcriptional regulatory mechanisms.
Medical subject headings
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Promoter Regions, Genetic
- Transcription, Genetic