Halting renal fibrosis: an unexpected role for mTORC2 signaling.
basic_science · Level V
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- Record sourced from PubMed, PMID 26323069.
- Also identified by DOI 10.1038/ki.2015.137.
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Abstract
Slowly progressive renal fibrosis is the hallmark of chronic kidney disease, independent of its etiology. Transforming growth factor-β (TGF-β) has been found to be the main profibrotic renal cytokine. Li et al. identify mTORC2 as an important mediator of TGF-β signaling. Being upstream of the previously described profibrotic kinases AKT, SGK1, and PKC-α, mTORC2 represents a potentially interesting drug target. Yet, although the mouse genetic approach yielded convincing results, transition from bench to bedside will remain challenging.
Medical subject headings
- Carrier Proteins
- Fibroblasts
- Kidney
- Kidney Diseases
- Multiprotein Complexes
- Signal Transduction
- TOR Serine-Threonine Kinases
- Transforming Growth Factor beta1