IgM in the kidney: a multiple personality disorder.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26323070.
- Also identified by DOI 10.1038/ki.2015.153 and PMC identifier 4556166.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
IgM in the blood of normal individuals consists mainly of 'natural' polyreactive antibodies. Natural IgM is thought to provide an initial defense against infection and to promote the healing of wounded cells. Yet, as Panzer and colleagues show, these benefits can be eclipsed when the IgM binds to damaged cells of the glomerulus, activating complement. IgM in glomeruli thus signifies cellular damage and may warn that the pace of that damage exceeds the capacity for repair.
Medical subject headings
- Complement Activation
- Complement Factor H
- Glomerulonephritis
- Immunoglobulin M
- Kidney Glomerulus