Nanoporous Metal-Phenolic Particles as Ultrasound Imaging Probes for Hydrogen Peroxide.

Guo, Junling; Wang, Xiaowei; Henstridge, Darren C; Richardson, Joseph J; Cui, Jiwei; Sharma, Arpeeta; Febbraio, Mark A; Peter, Karlheinz et al. · Adv Healthc Mater · 2015

basic_science · Level V

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Abstract

Nanoporous metal-phenolic particles are fabricated through the nanostructural replication of dense Fe<sup>III</sup> -TA complexes in nanoporous CaCO<sub>3</sub> template particles. The particles have potential for the diagnostic detection of endogenous levels of H<sub>2</sub> O<sub>2</sub> ex vivo and in vivo by ultrasound imaging, which is based on the catalytic activity of the coordinated Fe<sup>3+</sup> in the particles to break down H<sub>2</sub> O<sub>2</sub> to O<sub>2</sub> microbubbles.