Redox Modulation by Reversal of the Mitochondrial Nicotinamide Nucleotide Transhydrogenase.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26331603.
- Also identified by DOI 10.1016/j.cmet.2015.08.012.
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Abstract
The mitochondrial nicotinamide nucleotide transhydrogenase (NNT) uses the protonmotive force to transfer electrons from NADH to NADP, thereby maintaining the NADP/NADPH pool reduced to protect mitochondria from oxidative damage. In this issue, Nickel et al. (2015) show that NNT also operates in reverse, oxidizing the NADP/NADPH pool, thereby disrupting antioxidant defense.
Medical subject headings
- Heart Failure
- Mitochondria, Heart
- NADP
- NADP Transhydrogenases
- Oxidative Stress