Adaption by Rewiring Epigenetic Landscapes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26340521.
- Also identified by DOI 10.1016/j.stem.2015.08.015 and PMC identifier 4710369.
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Abstract
Embryonic stem cells (ESCs) generally rely on repressive histone modifications to silence retrotransposons, rather than DNA methylation as in differentiated cells. In this issue of Cell Stem Cell, He et al. (2015) show that Daxx/Atrx repress transposons in ESCs devoid of 5mC, demonstrating dynamic reorganization of epigenetic networks and crosstalk between distinct repressive mechanisms to maintain transposon silencing.
Medical subject headings
- Adaptor Proteins, Signal Transducing
- Carrier Proteins
- DNA Helicases
- DNA Methylation
- Histones
- Intracellular Signaling Peptides and Proteins
- Lysine
- Nuclear Proteins
- Tandem Repeat Sequences