The Path from Pluripotency to Skeletal Muscle: Developmental Myogenesis Guides the Way.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26340524.
- Also identified by DOI 10.1016/j.stem.2015.08.017 and PMC identifier 4940037.
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Abstract
Following cues from mouse embryogenesis, Chal et al. (2015) identified key regulators of skeletal myogenesis from mouse and human pluripotent stem cells. Emerging myogenic progenitors were specified to form multinucleated fibers that enabled development of quiescent, satellite cell-like progenitors and a model for Duchenne Muscular Dystrophy.
Medical subject headings
- Cell Differentiation
- Disease Models, Animal
- Muscle Fibers, Skeletal
- Muscular Dystrophy, Duchenne
- Pluripotent Stem Cells