In Situ Formation of Nanofibers from Purpurin18-Peptide Conjugates and the Assembly Induced Retention Effect in Tumor Sites.
basic_science · Level V
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- Record sourced from PubMed, PMID 26350172.
- Also identified by DOI 10.1002/adma.201502598.
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Abstract
An assembly-induced retention effect for enhanced tumor photoacoustic (PA) imaging and therapeutics is described. A responsive small-molecule precursor is prepared that simultaneously self-assembles into nanofibers in tumor sites that exhibit an assembly-induced retention effect, which results in an improved PA imaging signal and enhanced therapeutic efficacy. This successful proof-of-concept study paves the way to develop novel supramolecular biomaterials for cancer diagnostics and therapeutics.
Medical subject headings
- Antineoplastic Agents
- Nanofibers
- Porphyrins