NS1: A corner piece in the dengue pathogenesis puzzle?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26355028.
- Also identified by DOI 10.1126/scitranslmed.aad1255.
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Abstract
Soluble dengue virus NS1 protein induces proinflammatory immune responses via Toll-like receptor 4 and disrupts endothelial cell integrity, resulting in vascular leakage (Beatty et al. and Modhiran et al., this issue).
Medical subject headings
- Cell Membrane Permeability
- Dengue Virus
- Endothelial Cells
- Toll-Like Receptor 4
- Vaccination
- Viral Nonstructural Proteins