Nutrient Competition: A New Axis of Tumor Immunosuppression.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26359979.
- Also identified by DOI 10.1016/j.cell.2015.08.064 and PMC identifier 6327313.
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Abstract
It is thought that cancer cells engage in Warburg metabolism to meet intrinsic biosynthetic requirements of cell growth and proliferation. Papers by Chang et al. and Ho et al. show that Warburg metabolism enables tumor cells to restrict glucose availability to T cells, suppressing anti-tumor immunity.
Medical subject headings
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Glycolysis
- Lymphocytes, Tumor-Infiltrating
- Melanoma
- Monitoring, Immunologic
- Neoplasms
- Phosphoenolpyruvate
- Tumor Microenvironment