Single-Cell Analysis: The Differences That Kill.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26359980.
- Also identified by DOI 10.1016/j.cell.2015.08.053.
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Abstract
Using single-cell RNA sequencing, Avraham et al. investigate how variability in macrophage response to infection is controlled by variability within the pathogen population. They find that heterogeneous expression of the Salmonella virulence factor PhoP and subsequent cell-wall modifications lead to the bimodal induction of the interferon-response in infected macrophages.
Medical subject headings
- Host-Pathogen Interactions
- Macrophages
- Salmonella typhimurium