Seek and Ye Shall Find: Subclonal Anaplastic Lymphoma Kinase Mutations.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26362998.
- Also identified by DOI 10.1158/1078-0432.CCR-15-1397 and PMC identifier 4631645.
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Abstract
Bellini and colleagues demonstrate the importance of next-generation sequencing to uncover subclonal anaplastic lymphoma kinase (ALK) mutations in neuroblastoma. Although the significance of these subclonal aberrations is not yet understood, deep sequencing could identify patients whose tumors may respond to ALK inhibitors.
Medical subject headings
- Clonal Evolution
- Mutation
- Neuroblastoma
- Receptor Protein-Tyrosine Kinases