The Functional Study of the N-Terminal Region of Influenza B Virus Nucleoprotein.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26368391.
- Also identified by DOI 10.1371/journal.pone.0137802 and PMC identifier 4569402.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Influenza nucleoprotein (NP) is a major component of the ribonucleoprotein (vRNP) in influenza virus, which functions for the transcription and replication of viral genome. Compared to the nucleoprotein of influenza A (ANP), the N-terminal region of influenza B nucleoprotein (BNP) is much extended. By virus reconstitution, we found that the first 38 residues are essential for viral growth. We further illustrated the function of BNP by mini-genome reconstitution, fluorescence microscopy, electron microscopy, light scattering and gel shift. Results show that the N terminus is involved in the formation of both higher homo-oligomers of BNP and BNP-RNA complex.
Medical subject headings
- Influenza B virus
- RNA, Viral
- Viral Core Proteins