Creation of a histone deacetylase 6 inhibitor and its biological effects [corrected].
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26371309.
- Also identified by DOI 10.1073/pnas.1515882112 and PMC identifier 4593111.
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Abstract
We report the development of a potent, selective histone deacetylase 6 (HDAC6) inhibitor. This HDAC6 inhibitor blocks growth of normal and transformed cells but does not induce death of normal cells. The HDAC6 inhibitor alone is as effective as paclitaxel in anticancer activity in tumor-bearing mice.
Medical subject headings
- Antineoplastic Agents
- Benzeneacetamides
- Histone Deacetylase Inhibitors
- Histone Deacetylases
- Hydroxamic Acids