The B-cell antigen receptor integrates adaptive and innate immune signals.
basic_science · Level V
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- Record sourced from PubMed, PMID 26371314.
- Also identified by DOI 10.1073/pnas.1516428112 and PMC identifier 4593120.
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Abstract
B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-dependent activation of phosphoinositidyl 3-kinase (PI-3K) signaling. Glycogen synthase kinase 3β and Foxo1 are two PI-3K-regulated targets that play important roles, but to different extents, depending on the specific mitogen. These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response.
Medical subject headings
- Adaptive Immunity
- Cell Proliferation
- Immunity, Innate
- Models, Immunological
- Receptors, Antigen, B-Cell
- Signal Transduction