Physiological Mechanisms of Weight Gain-Induced Steatosis in People With Obesity.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 26376348.
- Also identified by DOI 10.1053/j.gastro.2015.09.003 and PMC identifier 4691551.
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Abstract
Weight gain is associated with an increase in intrahepatic triglycerides (IHTGs), and is the primary cause of nonalcoholic fatty liver disease in obese individuals. We combined imaging and stable isotope tracer techniques to evaluate the physiologic mechanisms of weight gain-induced steatosis in 27 obese people. Weight gain appeared to increase IHTG content by generating an imbalance between hepatic fatty acid availability and disposal, and resulted in increased hepatic de novo lipogenesis, decreased intrahepatic fatty acid oxidation, and inadequate increases in IHTG export via very low-density lipoprotein secretion. ClinicalTrials.gov ID NCT01184170.
Medical subject headings
- Body Composition
- Fatty Liver
- Lipid Metabolism
- Obesity
- Weight Gain