Targeting the glucocorticoid receptor in breast and prostate cancers.
Level V
Where this comes from
- Record sourced from PubMed, PMID 26378243.
- Also identified by DOI 10.1126/scitranslmed.aac7531 and PMC identifier 4807967.
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Abstract
Steroid receptors for androgens and estrogens have essential roles in prostate and breast cancers. Recently, glucocorticoid receptor (GR) activity has also been proposed as having an important role in these cancers. Underscoring the cooperative nature of nuclear receptor activity, data now suggest that GR function in prostate and breast cancers is dependent on the tumor's concomitant androgen or estrogen receptor activity.
Medical subject headings
- Breast Neoplasms
- Gene Expression Regulation, Neoplastic
- Prostatic Neoplasms
- Receptors, Glucocorticoid