P-SAMS: a web site for plant artificial microRNA and synthetic trans-acting small interfering RNA design.

Fahlgren, Noah; Hill, Steven T; Carrington, James C; Carbonell, Alberto · Bioinformatics · 2016

basic_science · Level V

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Abstract

The Plant Small RNA Maker Site (P-SAMS) is a web tool for the simple and automated design of artificial miRNAs (amiRNAs) and synthetic trans-acting small interfering RNAs (syn-tasiRNAs) for efficient and specific targeted gene silencing in plants. P-SAMS includes two applications, P-SAMS amiRNA Designer and P-SAMS syn-tasiRNA Designer. The navigation through both applications is wizard-assisted, and the job runtime is relatively short. Both applications output the sequence of designed small RNA(s), and the sequence of the two oligonucleotides required for cloning into 'B/c' compatible vectors. The P-SAMS website is available at http://p-sams.carringtonlab.org. acarbonell@ibmcp.upv.es or nfahlgren@danforthcenter.org.

Medical subject headings