Aging as a driver of leukemogenesis.
Level V
Where this comes from
- Record sourced from PubMed, PMID 26400908.
- Also identified by DOI 10.1126/scitranslmed.aac4428 and PMC identifier 4916992.
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Abstract
The presence of subclinical hemopoietic clones driven by leukemia-associated mutations is commonly observed in old age, but also occurs in younger people. We recently found that some leukemia-initiating mutations appear <i>particularly</i> able to found hemopoietic clones in advanced old age. We discuss the biological and clinical implications of these findings.
Medical subject headings
- Aging
- Leukemia