A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26414883.
- Also identified by DOI 10.1002/adma.201503093.
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Abstract
New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.
Medical subject headings
- Anti-Inflammatory Agents
- Nanostructures
- Peptide Fragments
- Protein C
- Receptors, Thrombin
- Sepsis