Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b+ dendritic cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 26417101.
- Also identified by DOI 10.1073/pnas.1513532112 and PMC identifier 4611596.
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Abstract
Intranasal (i.n.) infections preferentially generate Th17 cells. We explored the basis for this anatomic preference by tracking polyclonal CD4(+) T cells specific for an MHC class II-bound peptide from the mucosal pathogen Streptococcus pyogenes. S. pyogenes MHC class II-bound peptide-specific CD4(+) T cells were first activated in the cervical lymph nodes following i.n. inoculation and then differentiated into Th17 cells. S. pyogenes-induced Th17 formation depended on TGF-β1 from dendritic cells and IL-6 from a CD301b(+) dendritic cell subset located in the cervical lymph nodes but not the spleen. Thus, the tendency of i.n. infection to induce Th17 cells is related to cytokine production by specialized dendritic cells that drain this site.
Medical subject headings
- Dendritic Cells
- Interleukin-6
- Lectins, C-Type
- Nose Diseases
- Streptococcal Infections
- Streptococcus pyogenes
- Th17 Cells
- Transforming Growth Factor beta1