Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26418302.
- Also identified by DOI 10.1021/acs.nanolett.5b03073 and PMC identifier 5507193.
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Abstract
More than 50% of all cancer patients receive radiation therapy. The clinical delivery of curative radiation dose is strictly restricted by the proximal healthy tissues. We propose a dual-targeting strategy using vessel-targeted-radiosensitizing gold nanoparticles and conformal-image guided radiation therapy to specifically amplify damage in the tumor neoendothelium. The resulting tumor vascular disruption substantially improved the therapeutic outcome and subsidized the radiation/nanoparticle toxicity, extending its utility to intransigent or nonresectable tumors that barely respond to standard therapies.
Medical subject headings
- Gold
- Metal Nanoparticles
- Neoplasms
- Neovascularization, Pathologic