Epigenetic regulation in acute kidney injury: new light in a dark area.
Level V
Where this comes from
- Record sourced from PubMed, PMID 26422622.
- Also identified by DOI 10.1038/ki.2015.229 and PMC identifier 4734625.
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Abstract
Epigenetic mechanisms have been implicated in the pathogenesis of renal diseases, including acute kidney injury (AKI). Mar et al. now unravel the acetylation and methylation at histones that are associated with the transcription of key genes in AKI. Notably, histone modifications display a remarkable heterogeneity in ischemic and endotoxic AKI. Targeting epigenetic programs may offer novel strategies to protect kidneys from AKI and enhance kidney repair and recovery.
Medical subject headings
- Acute Kidney Injury
- Epigenesis, Genetic
- Kidney
- Lipopolysaccharides
- Reperfusion Injury