Epigenetic control of podocyte differentiation: a new target of the renin-angiotensin system in kidney disease.
Level V
Where this comes from
- Record sourced from PubMed, PMID 26422623.
- Also identified by DOI 10.1038/ki.2015.224.
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Abstract
Glomerular podocyte integrity is essential to limit protein filtration in the urine. Hayashi et al. report that epigenetic mechanisms control podocyte differentiation and that activation of the renin-angiotensin system in kidney disease affects podocyte differentiation and proteinuria by resetting the podocyte epigenome. These findings suggest that modulation of DNA methylation could be a promising target for the control of proteinuric kidney disease.
Medical subject headings
- Albuminuria
- Angiotensin II Type 1 Receptor Blockers
- Benzimidazoles
- Biphenyl Compounds
- Epigenesis, Genetic
- Kruppel-Like Transcription Factors
- Podocytes
- Renal Insufficiency, Chronic
- Renin-Angiotensin System
- Tetrazoles