Patient-derived orthotopic xenografts: better mimic of metastasis than subcutaneous xenografts.
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- Record sourced from PubMed, PMID 26422835.
- Also identified by DOI 10.1038/nrc3972.
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Abstract
The majority of human solid tumours do not metastasize when grown subcutaneously in immunocompromised mice; this includes patient-derived xenograft (PDX) models. However, orthotopic implantation of intact tumour tissue can lead to metastasis that mimics that seen in patients. These patient-derived orthotopic xenograft (PDOX) models have a long history and might better recapitulate human tumours than PDX models.
Medical subject headings
- Neoplasms, Experimental