missMethyl: an R package for analyzing data from Illumina's HumanMethylation450 platform.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26424855.
- Also identified by DOI 10.1093/bioinformatics/btv560.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
UNLABELLED: DNA methylation is one of the most commonly studied epigenetic modifications due to its role in both disease and development. The Illumina HumanMethylation450 BeadChip is a cost-effective way to profile >450 000 CpGs across the human genome, making it a popular platform for profiling DNA methylation. Here we introduce missMethyl, an R package with a suite of tools for performing normalization, removal of unwanted variation in differential methylation analysis, differential variability testing and gene set analysis for the 450K array. AVAILABILITY AND IMPLEMENTATION: missMethyl is an R package available from the Bioconductor project at www.bioconductor.org. CONTACT: alicia.oshlack@mcri.edu.au SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Medical subject headings
- Computational Biology
- DNA Methylation
- Genome, Human
- Oligonucleotide Array Sequence Analysis
- Software