ANARCI: antigen receptor numbering and receptor classification.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26424857.
- Also identified by DOI 10.1093/bioinformatics/btv552 and PMC identifier 4708101.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Antibody amino-acid sequences can be numbered to identify equivalent positions. Such annotations are valuable for antibody sequence comparison, protein structure modelling and engineering. Multiple different numbering schemes exist, they vary in the nomenclature they use to annotate residue positions, their definitions of position equivalence and their popularity within different scientific disciplines. However, currently no publicly available software exists that can apply all the most widely used schemes or for which an executable can be obtained under an open license. ANARCI is a tool to classify and number antibody and T-cell receptor amino-acid variable domain sequences. It can annotate sequences with the five most popular numbering schemes: Kabat, Chothia, Enhanced Chothia, IMGT and AHo. ANARCI is available for download under GPLv3 license at opig.stats.ox.ac.uk/webapps/anarci. A web-interface to the program is available at the same address. deane@stats.ox.ac.uk.
Medical subject headings
- Antibodies
- Computational Biology
- Immunoglobulin Variable Region
- Receptors, Antigen, T-Cell
- Software