Configurable lipid membrane gradients quantify diffusion, phase separations and binding densities.

Liu, Katherine N; Hung, Chen-Min S; Swift, Michael A; Muñoz, Kristen A; Cortez, Jose L; Sanii, Babak · Soft Matter · 2015

basic_science · Level V

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Abstract

Single-experiment analysis of phospholipid compositional gradients reveals diffusion coefficients, phase separation parameters, and binding densities as a function of localized lipid mixture. Compositional gradients are formed by directed self assembly where rapid-prototyping techniques (i.e., additive manufacturing or laser-cutting) prescribe lipid geometries that self-spread, heal and mix by diffusion.

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