Moving Toward the Ground State.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26431178.
- Also identified by DOI 10.1016/j.stem.2015.09.009.
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Abstract
Transferring mouse ESCs to a media supplemented with Mek and Gsk3β inhibitors (2i) provokes marked transcriptional and epigenetic changes, embodying a shift toward ground-state pluripotency. In this issue of Cell Stem Cell, Kolodziejczyk et al. (2015) examine population structures of ESCs while Galonska et al. (2015) unravel the mechanisms underlying regulatory network rewiring during 2i-mediated reprogramming.
Medical subject headings
- Epigenesis, Genetic
- Mouse Embryonic Stem Cells
- RNA
- Transcriptome