IGFBP3 and T1D: Systemic Factors in Colonic Stem Cell Function and Diabetic Enteropathy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26431180.
- Also identified by DOI 10.1016/j.stem.2015.09.008.
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Abstract
Patients with type 1 diabetes (T1D) often experience gastrointestinal enteropathy (DE) of unclear etiology. Now in Cell Stem Cell, D'Addio et al. (2015) utilize organoid culture models to study the roles of stem cells in DE and show that circulating IGF/IGFBP3 controls colonic stem cell function during homeostasis and in T1D patients.
Medical subject headings
- Colon
- Diabetes Complications
- Diabetes Mellitus, Experimental
- Insulin-Like Growth Factor Binding Protein 3
- Insulin-Like Growth Factor I
- Stem Cells