ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26433221.
- Also identified by DOI 10.1093/infdis/jiv476 and PMC identifier 7107392.
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Abstract
Several lineage B betacoronaviruses termed severe acute respiratory syndrome (SARS)-like CoVs (SL-CoVs) were identified from Rhinolophus bats in China. These viruses are characterized by a set of unique accessory open reading frames (ORFs) that are located between the M and N genes. Among unique accessory ORFs, ORF8 is most hypervariable. In this study, the ORF8s of all SL-CoVs were classified into 3 types, and, for the first time, it was found that very few SL-CoVs from Rhinolophus sinicus have ORF8s that are identical to that of human SARS-CoV. This finding provides new genetic evidence for Chinese horseshoe bats as the source of human SARS-CoV.
Medical subject headings
- Chiroptera
- Evolution, Molecular
- Severe acute respiratory syndrome-related coronavirus
- Viral Matrix Proteins