Making Biological Sense of GWAS Data: Lessons from the FTO Locus.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 26445508.
- Also identified by DOI 10.1016/j.cmet.2015.09.018.
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Abstract
GWAS have yielded many candidate loci for complex diseases like obesity, but interpreting the biological context of these findings has been difficult. Claussnitzer et al. (2015) use a sophisticated combination of bioinformatic and experimental approaches to address this bottleneck for variants in the FTO locus that associate with obesity.
Medical subject headings
- Adipocytes
- Obesity
- Proteins
- Thermogenesis