Running on Empty: Leptin Signaling in VTA Regulates Reward from Physical Activity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26445509.
- Also identified by DOI 10.1016/j.cmet.2015.09.021.
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Abstract
Hunger increases physical activity and stamina to support food-directed foraging behaviors, but underlying mechanisms are unclear. In this issue, Fernandes et al. (2015) show that disruption of leptin-regulated STAT3 signaling in midbrain dopamine neurons increases the rewarding effects of running in mice, which could explain the "high" experienced by endurance runners.
Medical subject headings
- Dopaminergic Neurons
- Leptin
- STAT3 Transcription Factor
- Signal Transduction