Beyond Hit-and-Run: Stem Cells Leave a Lasting Memory.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26445510.
- Also identified by DOI 10.1016/j.cmet.2015.09.019.
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Abstract
While mesenchymal stem cells (MSCs) are rapidly cleared from the body following systemic transplantation, their therapeutic benefits typically persist. In this issue, Liu et al. (2015) reveal that the ability of transplanted MSCs to alleviate osteoporosis in systemic lupus erythematosus is maintained through epigenetic changes conferred by secretory action of the MSCs.
Medical subject headings
- Epigenesis, Genetic
- Mesenchymal Stem Cells
- Receptor, Notch1
- Signal Transduction