Companion animals: Translational scientist's new best friends.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 26446953.
- Also identified by DOI 10.1126/scitranslmed.aaa9116 and PMC identifier 4806851.
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Abstract
Knowledge and resources derived from veterinary medicine represent an underused resource that could serve as a bridge between data obtained from diseases models in laboratory animals and human clinical trials. Naturally occurring disease in companion animals that display the defining attributes of similar, if not identical, diseases in humans hold promise for providing predictive proof of concept in the evaluation of new therapeutics and devices. Here we outline comparative aspects of naturally occurring diseases in companion animals and discuss their current uses in translational medicine, benefits, and shortcomings. Last, we envision how these natural models of disease might ultimately decrease the failure rate in human clinical trials and accelerate the delivery of effective treatments to the human clinical market.
Medical subject headings
- Disease Models, Animal
- Translational Research, Biomedical