Nuclear-Targeting MSNs-Based Drug Delivery System: Global Gene Expression Analysis on the MDR-Overcoming Mechanisms.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26450832.
- Also identified by DOI 10.1002/adhm.201500548.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The biological mechanisms of nuclear-targeting mesoporous silica nanoparticles (MSNs)-based DDSs (DOX@NT-MSNs) in overcoming multidrug resistance of cancer cells are studied. It is interesting to find for the first time that DOX@NT-MSNs down-regulate the expression of apoptosis suppressor genes and inhibit DNA repair process by disturbing the p53 pathway.
Medical subject headings
- Doxorubicin
- Drug Resistance, Multiple
- Nanoparticles
- Silicon Dioxide