Fleeting Amyloid-like Forms of Rim4 Ensure Meiotic Fidelity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26451477.
- Also identified by DOI 10.1016/j.cell.2015.09.049 and PMC identifier 4653133.
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Abstract
Berchowitz et al. establish that transient amyloid-like forms of Rim4, a yeast RNA-binding protein with a predicted prion domain, translationally repress cyclin CLB3 in meiosis I, thereby ensuring homologous chromosome segregation. These findings suggest that prion domains might enable formation of tightly regulated amyloid-like effectors in diverse functional settings.
Medical subject headings
- Gametogenesis
- Protein Aggregates
- RNA-Binding Proteins
- Saccharomyces cerevisiae Proteins