Genomic integrity and the ageing brain.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 26462757.
- Also identified by DOI 10.1038/nrn4020.
- No licence information is recorded for this record.
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Abstract
DNA damage is correlated with and may drive the ageing process. Neurons in the brain are postmitotic and are excluded from many forms of DNA repair; therefore, neurons are vulnerable to various neurodegenerative diseases. The challenges facing the field are to understand how and when neuronal DNA damage accumulates, how this loss of genomic integrity might serve as a 'time keeper' of nerve cell ageing and why this process manifests itself as different diseases in different individuals.
Medical subject headings
- Aging
- Brain
- DNA Damage
- Genomics