Enhancing Pharmacokinetics, Tumor Accumulation, and Antitumor Efficacy by Elastin-Like Polypeptide Fusion of Interferon Alpha.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26463662.
- Also identified by DOI 10.1002/adma.201503440.
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Abstract
Genetic fusion of elastin-like polypeptide (ELP) to the C-terminus of interferon alpha (IFN) generates a well-defined IFN-ELP fusion protein with high yield and well-retained bioactivity. The fusion protein significantly enhances pharmacokinetics, tumor accumulation, and antitumor efficacy of interferon alpha in a murine cancer model.
Medical subject headings
- Antineoplastic Agents
- Interferon-alpha
- Peptides
- Recombinant Fusion Proteins