Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRLlpr Mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26465326.
- Also identified by DOI 10.1371/journal.pone.0140173 and PMC identifier 4605611.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The role of IL-18 in the pathogenesis of systemic lupus erythematosus is still not definitively solved. In this study, we generated MRLlpr mice, which develop a disease resembling systemic lupus erythematosus, genetically devoid of IL-18 expression. These mice in comparison to IL-18-competent MRLlpr mice show reduced signs of renal pathogenesis, while other parameters such as mean survival time, lymphadenopathy, constitutive interferon-γ production, and frequency of CD3+B220+ abnormal T cells were without differences. We conclude that in the systemic lupus erythematosus syndrom IL-18 is involved specifically in the renal pathogenesis.
Medical subject headings
- Interleukin-18
- Kidney
- Lupus Erythematosus, Systemic
- Renal Insufficiency