Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 26469986.
- Also identified by DOI 10.1371/journal.pone.0140773 and PMC identifier 4607156.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
During an HIV-1 prevention clinical trial in East Africa, we observed 16 cases of primary HIV-1 infection in women coincident with pregnancy or breastfeeding. Nine of eleven pregnant women initiated rapid combination antiretroviral therapy (ART), despite having CD4 counts exceeding national criteria for ART initiation; breastfeeding women initiated ART or replacement feeding. Rapid ART initiation during primary HIV-1 infection during pregnancy and breastfeeding is feasible in this setting.
Medical subject headings
- Anti-HIV Agents
- Breast Feeding
- Early Medical Intervention
- HIV Infections
- Infectious Disease Transmission, Vertical
- Pregnancy Complications, Infectious